Only combine Delta-8 with other substances with your doctor's approval and avoid combining Delta-8 with other recreational substances or alcohol. The first option, and the most obvious one, is to simply avoid Delta-8 when the drug test date approaches. Depending on your tolerance level and size, among other things, THC can remain in your body for more than 2 months, so you'll have to plan accordingly if abstinence is going to be your method. The PCC states that delta-8-THC can cause harmful reactions if more than one “dose” is taken.
Some of those reactions, Scharman says, can affect mental functioning, breathing and the heart. It can also be dangerous if a child takes a single dose.
Delta 8THC is one of the most popular derivatives of the hemp plant, and is second only to organic CBD products. Therefore, THC Delta 8, which acts as a CYP3A4 inhibitor, can cause certain drugs to accumulate in toxic concentrations in the body, which is the basis of the possible interaction.
As a hemp-derived cannabinoid, THC delta 8 is classified as a non-toxic substance, helping people feel comfortable incorporating it into their lifestyles. If you are taking delta 8 hemp-derived products along with another CYP3A4 inhibitor, such as drinking grapefruit juice every morning, this will have a greater impact on how medications can be metabolized. Ultimately, the only way to know if you can safely take Delta 8 THC and a particular prescription drug is to talk to your doctor. At the end of the day, it's good to take a “prevention is better than cure” approach when it comes to mixing Delta 8 hemp products with prescription drugs.
The reason why so many people are concerned about the possible interaction between Delta 8 hemp products and certain prescription drugs is due to the relationship between the cannabinoid and a metabolite called CYP3A4.